ea0093oc18 | Oral communication 3: Adrenal Tumors and Neuroendocrine Tumors | EYES2023
Maier Tanja
, Landwehr Laura-Sophie
, Sbiera Silviu
, Schauer Marc P.
, Schwarzmuller Paul
, Fassnacht Martin
, Kroisz Matthias
Background: Immune checkpoint therapy response rate in adrenocortical carcinoma (ACC) is only ~15%. Glucocorticoid (GC) secretion is present in ~60% of tumours, associated with adverse outcome and has been associated with an immunologically cold tumoural microenvironment. On the other hand, activation of the Wnt/ß-Catenin pathway has been suggested to contribute to reduced immune infiltration.Aims: First, we aim to improve the understanding of cellu...